Educational animation for teaching G-protein signal transduction

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G-proteins are cell membrane-spanning proteins that detect and convey extracellular messages by numerous cellular signaling agents, including peptide hormones and sensory stimuli. G-proteins convert the extracellular messages into intracellular second messengers that direct the cell to respond physiologically. G-proteins are major targets for drug discovery and design for new pharmaceuticals.

Scene-1 demonstrates how a signaling molecule such as a hypothetical peptide hormone interacts with an extracellular receptor binding site to convey its message to the cell followed by a cellular response such as a cation channel opening to produce a depolarization in the cell membrane as the cellular response.

Scene 2 explains how the hormone signal is conveyed from the hormone to the receptor, through the cell plasma membrane, into the cell and activates a G-protein associated with the receptor. The scene then shows the details of how the G-protein then starts a cascade of intracellular second messengers that ultimately activate a protein kinase enzyme.

Scene 3 shows how the activated protein kinase phosphorylates a membrane cation channel to activate the channel and cause it to open so that cations can diffuse into the cell and produce a membrane depolarization as the cellular physiological response to the initial hormonal signal.

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Testimonials:

I liked your G-protein movie greatly. I would like to show it to my medical school class in physiology as a teaching tool to underscore my lecture if you don’t mind. - C.R., Edward Via College of Osteopathic Medicine, Virginia Polytechnic Institute and State University

Hello, I’m a student taking an endocrinology class via distance learning. As such, classroom instruction can be very limited. … Your website is awesome at explaining what occurs. I will definitely be recommending it to my instructor. - C.

Hi … I am studying Cell + Molecular Biology at Aston University in England. I would just like to thank you quickly, I came across your website and until watching your movie had never fully understood the whole process of signal transduction by G proteins. It was very clear and to the point, and I am now hoping that it comes up in my exams! thanks again, - J.S.

I am a student in UBC and the animation my professor showed us in the lecture was way too fast. Therefore, I really appreciate your animation, because it's divided into various steps. I have no problem understanding it after watching it a few times. I like it how you can pause and think. - A.A.

I am a retired academic but continue to occupy a desk in my former Biochem and Mol Biol dept. I spent most of my employed years teaching 'Science in context' including, for instance, a course in 'Biotechnology in context'. I have attended the occasional seminar dealing with aspects of your animation's topic and also briefly read about it in Alberts et al.

I found your animation, mentioned to me by a colleague, quite simply 'bloody brilliant'. I shall return to Alberts et al and then spend a leisurely hour or so with the animation again in the near future and, for the first time, feel confident of gaining an understanding all of sorts of things that I have wondered about but never before satisfactorily sorted out.

I am therefore not using your animation for teaching in the ordinary sense. But I have begun to use it to teach myself, and feel enormously impressed with its likely effectiveness as a (1) motivator, as a (2) source of explanation and also as a (3) source of actual retention, always a problem, especially for a 66 year-old-mind. - J.E.

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